• 
  Sharon Bridgeman

  regizor

• 
  Hugh Jackman

  Gabriel Van Helsing (voce)
• 
  Robbie Coltrane

  dl. Hyde (voce)
• 
  Dwight Schultz

  Dr. Jekyll (voce)
• 
  Tress MacNeille

  Queen Victoria
• 
  David Wenham

  Carl
• 
  Julia Fletcher

  Lady In Waiting
• 
  Roger Jackson

  Drunken Gentleman

• 
  Tara Strong

  Young Victoria
• 
  John DiMaggio

  Coachman
• 
  Grey Griffin

  First Victim
• 
  James Arnold Taylor

  Voci adiţionale