• 
  Mike White

  regizor

• 
  Mike White

  scenarist

• 
  Molly Shannon

  Peggy
• 
  Laura Dern

  Bret
• 
  Regina King

  Layla
• 
  Tom McCarthy

  Pier
• 
  Josh Pais

  Robin
• 
  John C. Reilly

  Al

• 
  Peter Sarsgaard

  Newt
• 
  Amy Schlagel

  Lissie
• 
  Jimmy the Dog

  Dog
• 
  Sonya Eddy

  Nurse
• 
  Brenda Canela

  Brenda
• 
  Audrey Wasilewski

  Audrey
• 
  Zoe Schlagel

  Lissie

• 
  Liza Weil

  Trishelle
• 
  Dale Godboldo

  Don
• 
  Christy Moore

  Al's Girlfriend (as Christy Lynn Moore)
• 
  Inara George

  Holly
• 
  Jon Shere

  Pound Employee