• 
  Megumi Ogata

  Yugi Moto
• 
  Shunsuke Kazama

  Yugi Moto
• 
  Kenjirô Tsuda

  Seto Kaiba (voice)
• 
  Dan Green

  Yugi Moto
• 
  Masami Iwasaki

  Isono (voice)
• 
  Hidehiro Kikuchi

  Hiroto Honda (voice)
• 
  Kazunari Kojima

  Black Magician (voice)
• 
  Satoshi Hino

  Mani (voice)

• 
  Kend

  Kudaragi (voice)
• 
  Kento Hayashi

  Aigami / Deeva (voice)
• 
  Kana Hanazawa

  Sera (voice)
• 
  Aki Kanada

  Additional Voices (voice)
• 
  Rina Endo

  Young Sera (voice)
• 
  Natsuki Kitakata

  Additional Voices (voice)
• 
  Ryôko Maekawa

  Additional Voices (voice)

• 
  Tatsuki Kobe

  Additional Voices (voice)
• 
  Laurie Hymes

  Serah (voice)
• 
  Daniel J. Edwards

  Aigami (voice)
• 
  Rina Endô

  Young Sera (voice)
• 
  Luis Alfonso

  Engineer (voice)
• 
  Victoria Granduke

  Lab Technician A (voice)
• 
  Bethany Cardinal

  Lab Technician B (voice)